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品系介紹

品系全名：C57BL/6JSmoc-Cd274^{em1(hPD-L1)Smoc}

目錄號(hào)：NM-HU-00062

品系狀態(tài)：活體

通過(guò)同源重組，將小鼠基因Cd274進(jìn)行人源化修飾。與此相似的品系還有hPD-L1(2)(NM-HU-190039),詳細(xì)信息請(qǐng)咨詢(xún)技術(shù)顧問(wèn)。

基本信息

基因名：Cd274

基因曾用名：B7h1， Pdl1， Pdcd1l1，Pdcd1lg1， A530045L16Rik

NCBI ID：60533

MGI ID：1926446

Ensembl ID：ENSMUSG00000016496

Pubmed：Cd274

人類(lèi)同源基因：CD274

相關(guān)數(shù)據(jù)

Fig1.?Expression of PD-L1 in the spleen lymphocytes collected from homozygous humanized PD-L1 mice and wild-type mice is detected by FACS. The results showed that the expression of human PD-L1 can be detected in both T cells and B cells collected from the spleen of homozygous humanized PD-L1 mice. (Completed in collaboration with CrownBio)

Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.  

Fig3. Immunotype in blood in hPD-L1 mice. 

Fig4. Immunotype in spleen in hPD-L1 mice. 

Fig5. Immunotype in bone marrow in hPD-L1 mice. 

Fig6. In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized PD-L1 mice. Homozygous humanized PD-L1 mice were inoculated with MC38 colon cancer cells (expressing human PDL1 rather than murine PD-L1). After the tumors grew to 100 mm3, the animals were randomly assigned into a control group and a treatment group (n=5). The results showed: The antibodies targeting human PD-L1 were associated with a very significant anti-tumor effect (TGI: tumor growth inhibition, p < 0.001), demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1.

相關(guān)品系

hCD274(BALB/c)品系名：BALB/cAnSmoc-Cd274^{em1(hCD274)Smoc}品系狀態(tài)：在研 | 目錄號(hào)：NM-HU-230465

hPD-L1(BALB/c,2)品系名：BALB/cAnSmoc-Cd274^{em2(hPD-L1)Smoc}品系狀態(tài)：在研 | 目錄號(hào)：NM-HU-230474

hPD-L1/hCD28品系名：C57BL/6JSmoc-Cd274^em1(hPD-L1)Cd28^{em2(hCD28)Smoc}品系狀態(tài)：活體 | 目錄號(hào)：NM-HU-210019

Cd274-Flox品系名：C57BL/6JSmoc-Cd274^{em1(flox)Smoc}品系狀態(tài)：活體 | 目錄號(hào)：NM-CKO-200298

hPD-L1(2)品系名：C57BL/6JSmoc-Cd274^{em2(hPD-L1)Smoc}品系狀態(tài)：活體 | 目錄號(hào)：NM-HU-190039

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注意事項(xiàng)

1.具體的試驗(yàn)周期以工程師告知的為準(zhǔn)。

2.文章中的圖片或者標(biāo)準(zhǔn)以及具體的試驗(yàn)方案僅供參考，因?yàn)槊總€(gè)樣品和項(xiàng)目都有所不同，所以最終以工程師告知的為準(zhǔn)。

3.關(guān)于（樣品量）的需求，最好是先咨詢(xún)我們的工程師確定，避免不必要的樣品損失。

4.加急試驗(yàn)周期一般是五個(gè)工作日左右，部分樣品有所差異

5.如果對(duì)于（hPD-L1）還有什么疑問(wèn)，可以咨詢(xún)我們的工程師為您一一解答。