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品系介紹

品系全名：C57BL/6JSmoc-Cd274^{em2(hPD-L1)Smoc}

目錄號(hào)：NM-HU-190039

品系狀態(tài)：活體

通過(guò)同源重組，將小鼠基因Cd274進(jìn)行人源化修飾。與此相似的品系還有hPD-L1(NM-HU-00062),詳細(xì)信息請(qǐng)咨詢技術(shù)顧問(wèn)。

基本信息

基因名：Cd274

基因曾用名：B7h1， Pdl1， Pdcd1l1，Pdcd1lg1， A530045L16Rik

NCBI ID：60533

MGI ID：1926446

Ensembl ID：ENSMUSG00000016496

Pubmed：Cd274

人類(lèi)同源基因：CD274

相關(guān)數(shù)據(jù)

Fig1.?The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 

Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice. 

Fig3. Immunotype in blood in hPD-L1 mice. 

Fig4. Immunotype in spleen in hPD-L1 mice. 

Fig5. Immunotype in bone marrow in hPD-L1 mice. 

Fig6.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.

相關(guān)品系

hCD274(BALB/c)品系名：BALB/cAnSmoc-Cd274^{em1(hCD274)Smoc}品系狀態(tài)：在研 | 目錄號(hào)：NM-HU-230465

hPD-L1(BALB/c,2)品系名：BALB/cAnSmoc-Cd274^{em2(hPD-L1)Smoc}品系狀態(tài)：在研 | 目錄號(hào)：NM-HU-230474

hPD-L1/hCD28品系名：C57BL/6JSmoc-Cd274^em1(hPD-L1)Cd28^{em2(hCD28)Smoc}品系狀態(tài)：活體 | 目錄號(hào)：NM-HU-210019

Cd274-Flox品系名：C57BL/6JSmoc-Cd274^{em1(flox)Smoc}品系狀態(tài)：活體 | 目錄號(hào)：NM-CKO-200298

Cd274-KO(2)品系名：C57BL/6JSmoc-Cd274^em2Smoc品系狀態(tài)：活體 | 目錄號(hào)：NM-KO-18044

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注意事項(xiàng)

1.具體的試驗(yàn)周期以工程師告知的為準(zhǔn)。

2.文章中的圖片或者標(biāo)準(zhǔn)以及具體的試驗(yàn)方案僅供參考，因?yàn)槊總€(gè)樣品和項(xiàng)目都有所不同，所以最終以工程師告知的為準(zhǔn)。

3.關(guān)于（樣品量）的需求，最好是先咨詢我們的工程師確定，避免不必要的樣品損失。

4.加急試驗(yàn)周期一般是五個(gè)工作日左右，部分樣品有所差異

5.如果對(duì)于（hPD-L1(2)）還有什么疑問(wèn)，可以咨詢我們的工程師為您一一解答。